| # | Unlocked | Locked | Name | Beschreibung | Spieler | Global |
|---|---|---|---|---|---|---|
| 1 |
|
| One-Eyed Freak | Defeat the Cycloid | 8 | 89.9% |
| 2 |
|
| Drawrings | Doodle something on the whiteboard in SP | 9 | 88.4% |
| 3 |
|
| Flagon of Chuckles | Drink a beer in SP | 8 | 83.7% |
| 4 |
|
| Extermination | Kill 50 aliens | 8 | 81.8% |
| 5 |
|
| Juiced | Take steroids in SP | 8 | 79.6% |
| 6 |
|
| Nobody Likes a Whiner | Knock out the talent at the talk show | 8 | 75.1% |
| 7 |
|
| Annihilation | Kill 100 aliens | 8 | 71.4% |
| 8 |
|
| Natural Disaster 3x | Kill 3 aliens at once | 8 | 66.2% |
| 9 |
|
| Pit Champion | Defeat the Battlelord in Las Vegas | 7 | 59.5% |
| 10 |
|
| Nuclear Devastation | Kill 250 aliens | 6 | 57.4% |
| 11 |
|
| Big Guns, Big Ships | Blow up 5 enemy gunships or dropships | 8 | 55.3% |
| 12 |
|
| Baron von Nukem | Shoot down 20 alien fighters | 6 | 50.8% |
| 13 |
|
| Dead Useful | Kill 10 aliens with environmental explosives | 5 | 47.1% |
| 14 |
|
| On the Noggin' | Kill 30 aliens with headshots | 4 | 47% |
| 15 |
|
| Not Bad for a Human | Defeat the Alien Queen | 6 | 45.5% |
| 16 |
|
| Full Body Tourettes | Get knocked down 10 times | 3 | 41.6% |
| 17 |
|
| Road Rage | Kill 15 aliens with the monster truck | 5 | 41.5% |
| 18 |
|
| He's Got a Hologram! | Use a Holoduke in SP | 6 | 39.9% |
| 19 |
|
| I Need a Towel | Get hit by 10 Pregnator bombs | 4 | 38.4% |
| 20 |
|
| A Good Dam Fight | Defeat the Battlelord on the Hoover Dam | 5 | 37.7% |
| 21 |
|
| Turd Burglar | Find and steal a piece of poo | 8 | 37.6% |
| 22 |
|
| Octacide | Defeat the Octaking | 3 | 33.8% |
| 23 |
|
| Noms | Eat 10 pieces of food during the SP campaign | 5 | 31.6% |
| 24 |
|
| Beating the One-Eyed Worm | Defeat the Energy Leech | 3 | 29.9% |
| 25 |
|
| Piece of Cake | Complete the SP campaign on Easy Difficulty | 3 | 29.6% |
| 26 |
|
| Sticky Bomb Like You! | Put a Trip Mine on a live alien | 6 | 28.3% |
| 27 |
|
| Judge, Jury, Executioner | Execute 20 aliens | 5 | 28.1% |
| 28 |
|
| Substance Abuser | Drink beer while on steroids or vice-versa in SP | 6 | 26.9% |
| 29 |
|
| Fork the Pork | Kill 6 aliens with the forklift | 3 | 25.4% |
| 30 |
|
| Sunday, Black Sunday | Shoot down the blimp above the stadium | 3 | 24.9% |
| 31 |
|
| Hippy-Stomper | Foot stomp 12 aliens | 4 | 24.8% |
| 32 |
|
| Duke Angry, Duke Smash! | Kill 15 aliens with melee attacks while on steroids | 3 | 24.7% |
| 33 |
|
| Lots of Whacking | Win a game of Alien Abortion in the strip club | 5 | 21.6% |
| 34 |
|
| Let's Rock | Complete the SP campaign on Normal Difficulty | 2 | 17% |
| 35 |
|
| Tosser... in the Literal Sense | Kill 10 aliens with tossed objects | 2 | 17% |
| 36 |
|
| Trapper | Kill 10 aliens with Trip Mines | 2 | 13.3% |
| 37 |
|
| Special Thanks | Watch the credits all the way through | 3 | 11.7% |
| 38 |
|
| Freeze Well! | Kill 15 frozen aliens | 4 | 11.6% |
| 39 |
|
| I Need a Date | Look at every page of a calendar in SP | 3 | 10.5% |
| 40 |
|
| Air-Duke | Win air hockey with a score of 7-0 in the strip club | 4 | 8.8% |
| 41 |
|
| Gunslinger | Carry the gold pistol through the whole SP campaign | 1 | 6.1% |
| 42 |
|
| Party Animal | Drink all of the beers in the strip club | 4 | 5.2% |
| 43 |
|
| Come Get Some | Complete the SP campaign on Hard Difficulty | 1 | 5% |
| 44 |
|
| Companion Barrel | Unlock the secret closet at the end of the Forkstop | 2 | 4.6% |
| 45 |
|
| Balls of Steel | Earn a 1,000,000 pinball score in SP | 3 | 3.8% |
| 46 |
|
| Bucket Head | Find all 3 helmets in the SP campaign | 2 | 3.8% |
| 47 |
|
| I Am All That Is Man | Discover all ego cap rewards | 1 | 3.6% |
| 48 |
|
| Pescaphobe | Kill all of the catfish in the underwater level | 2 | 3.3% |
| 49 |
|
| Call Waiting | Listen to all phone messages | 1 | 3.3% |
| 50 |
|
| Damn, I'm Good | Complete the SP campaign on Insane Difficulty | 1 | 3% |